I am not sure I entirely understand your question regarding "piece of equipment," but I will assume that you mean profiles on the operating system and going through the workstation setup for each logon ID. This doesn't even work as you would hope because the notes.ini would be shared by all people on the machine.
The only way I could see this working for you would be with roaming users. However, as of the last time I tried it, the user had to be set up initially on a machine to have his roaming profile put into the proper directories. This was scheduled to be addressed by a future version, but I am unable to verify if it was fixed in 6.5.2. If it was fixed, you should be able to use roaming users to assist in your workstation setup issues. Each roaming user's personal information is kept on a Domino server and then copied to the workstation when Notes is started. After the session is terminated, the personal information (and any changes made during the session) is copied back to the Domino server and removed from the workstation.
This was first published in August 2004