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It is quite important to set up your SMTP MTA to not act as a relay, if you don't, MAPS (Mail Abuse Prevention System - a monitoring service that prevents spamming and Open Relay systems) can mark your system as an open relay and many domains will not accept mail from your domain.
If you are running Notes 4.6, you need to make changes in the Notes.ini file of the MTA server. To stop all relays, add the following parameters:
SMTP_OCH_REJECT_SMTP_ORIGINATED_MESSAGES=1 and SMTPMTA_RELAY_FORWARDS=1. To allow your POP3 users to send SMTP messages, add SMTPMTA_ALLOW_KNOWN_DOMAINS=1. This relays SMTP mail for domains listed in the Internet domain suffix of the Global Domain document. You should check the Knowledgebase for document #167173 --
This was first published in December 2000