What are the differences between Domino R4 and R6? To answer this completely would take a multi-volume book, but I can make a few general characterizations about the differences. R4 had minimal Web support, and the Designer was not distinguished from the Client. This was appropriate for the time in which it was developed. In 4.6, the Domino Web server had many enhancements that allowed users to deploy reasonable Web applications from...
If you install Domino 6, the Help has a nice feature ("What's New in 6?") that will explain the differences between R5 and 6.
Dig deeper on Domino Resources - Part 7
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