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For question 1, you would need to run Domino clustering. First, I would get off of 4.6 and onto 5.0.12 or 6.0.2 CF1. Second, there are licensing concerns with clustering, so you should check with your IBM rep to see if you have the proper license for clustering.
For question 2, either buy some filtering software (after you upgrade to R5 or D6) or use D6 mail rules and DNSBLs.
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