When agents use the On Schedule trigger, the run on schedule options box is available and includes the Don't run...
on weekends check box option.When you select this option, the agent does not run on weekend days. The default value for weekend days is Saturday (7) and Sunday (1). You can specify any number of days, up to 7. Example: Amgr_WeekendDays=1,5,7
This setting applies both to Servers and Workstations.