If you have ever had to reboot your server because a user is mysteriously locked out of their mail file in the morning, you may need to adjust your Veritas Backup Exec job specification! Basically, if you do a select all in the Backup Exec job definition, you will be backing up Domino files twice, once with the Domino agent and another using the file system agent. This can lead to not only backing up more data than required, but can actually lock domino databases open and therefore block access to users and the server.
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You may think that the resolution is to just exclude the Domino Data directory from the file system backup, but this will exclude important web server files required to run the http task. The resolution is to backup the file system volume, but add exclusions for *.nsf, *.ntf, *.box, *.dsk and *.ncf file, as the agent specifically backs these up.