'B-tree structure invalid' error when replicating to Mac OS

When replicating a large (c. 2 GB) database to the local hard disk on my Macintosh with OS 10.2.8 and Lotus Notes 6.5.1, I get an error message "B-tree structure invalid" and cannot open the local replica. By contrast, I can open any Domino server replica of the same database with no problem. I have read that the problem stems from a too-small buffer pool, but I don't know how to increase the size of the pool.
There could be several issues at play here. First, and I'll readily admit I know very little about the internals of Mac OS X, can it handle files over 2 GB? Some OS limitations can cause this error. Second, the buffer pool error is usually something you see on servers, not local clients. There is a notes.ini parameter to increase the pool, but I don't know if it works on clients, or for that matter, Macs. The parameter is NSF_Folder_Pool_Size_MB=n, where "n" is the value in MB. For a 2 GB file, you'd want this to be at least 2048. However, there are limits on this, which I cannot find documented right now, regarding how large it can be based on the amount of RAM you have. I believe it is only able to go up to one fourth of your RAM, so you'd need 8 GB of RAM to get around this error, if this is the solution.

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