There has been some work done on finding the most appropriate design patterns to use with Domino. I would point you in particular to these articles in The View:
- Using the MVC Design Pattern to Engineer Domino Web Applications
- Apply OO Analysis & Best Practices to Build a LotusScript Framework
Of course, you can write a Java applet, servlet or C++ program that just uses Notes as a back end for its data, but if you do that, you lose one big advantage of using Domino (i.e., that it does so much of the "view" work for you).
Dig Deeper on LotusScript
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