Currently we run Domino on AS/400 on its own partition -- it runs very well. There seems to be a push to move Domino to Windows-based Intel boxes for no other reason than just because management wants to.
Is there a short answer as to why we would or would not do this? I am against it; my opinion is that Windows is still a bit insecure and needs patching all the time. Also, the last time I ran Domino on Windows, it really did not run that well.
I'm an old advocate of, "If it ain't broke, don't fix it." Now, there could be many compelling reasons to both move or not to move. If Domino on the iSeries is performing well, and you have the ability to support it, then there is no reason to switch to Windows; Domino on the iSeries is far more scalable and reliable than Windows. If your corporate direction is to move all eligible applications to Windows and eliminate the need for supporting other operating systems, you'll have a hard time convincing the decision makers to rethink their choice. It really depends on scalability and what you need. If you have 10,000 users on that partition, then moving to Windows will require two or three very beefy servers to handle the load, and migration costs will be high. However, if you have 3,000 or less, then one Windows server will suffice, and migration costs will be negligible.
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