Mail is one of the biggest. There are many new options for managing mail that are useful, such as color coding of mail, follow ups, blocking mail and creating quick rules. View columns can be rearranged, and attachment handling has changed. Calendaring has lots of changes, too. You can get away with little training on the welcome page, although there are lots of new options there, too.
Dig Deeper on Lotus Notes Domino Interoperability
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