For programmatic changes to DB2 data -- i.e., those integrations that have business rules that do not fit neatly into the controls provided by LEI, you can use the Lotus Connector LSX and code custom integrations.
Another feature that was introduced in the Domino 6 product release is the Data Connection Resource, or "DCR." DCRs are shared resources that can be referenced within the properties of a Field. For complete details on DCRs, look in the Design Help Database (thankfully it's pretty detailed and useful help).
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