It all depends on your network. For replication, I always say "hub/spoke" because it offers you the most control and consistency. For mail routing, if you have the bandwidth, put everyone in the same Domino Named Network and let them route in a "star" pattern -- it offers the most flexibility. Remember, mail and replication topologies are separate entities.
Dig Deeper on Lotus Notes Domino Replication and Synchronization
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