Optimize Domino server response and overall server performance

One of our customers has a Domino server 6.5 as an application server. Recently, users are complaining about the slow response of the server for particular databases. Sometimes the server hangs. The databases are about the size of 16 GB. How can we optimize the server response and overall server performance?
16 GB is a large database. The key here is to try and keep views as small as possible, and keep the data refreshes to a minimum. A large database that is receiving numerous changes all day will never be a performance star. You need to try and break up views to keep them from growing too large, and you should try staging changes to the database on a separate server or database. Then, you can release the changes in an orderly fashion and keep the views fresh. Other than that, you should look at your hardware to make sure there aren't any I/O bottlenecks.

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